Visible?Light?Driven Catalytic Deracemization of Secondary Alcohols

Catalytic dehydration of alcohols

One-Pot Deracemization of sec-Alcohols: Enantioconvergent Enzymatic Hydrolysis of Alkyl Sulfates Using Stereocomplementary Sulfatases**

Given the fact that the theoretically possible number of racemates is larger than that of symmetric prochiral or meso compounds, the development of deracemization methods, which yield a single stereoisomer from a racemate is an important topic. Enantioconvergent processes are based on the transformation of a pair of enantiomers through opposite stereochemical pathways affecting retention and in...

Catalytic enantioselective bromoamination of allylic alcohols.

An enantioselective bromoamination of allylic alcohols has been developed for the first time using a newly designed cinchona-derived thiourea as the catalyst and N,N-dibromo-4-nitrobenzenesulfonamide as a bromine and amine source.

Catalytic enantioselective dibromination of allylic alcohols.

A new dibromination reaction involving the combination of dibromomalonate as the bromonium source and a titanium bromide species as the bromide source has been developed. Enantioselective catalysis has been achieved through apparent ligand acceleration by a tartaric acid-derived diol.

Ni-catalysed, domino synthesis of tertiary alcohols from secondary alcohols.

The use of in situ generated (NHC)-Ni catalytic species (NHC = N-heterocyclic carbene) allows for the synthesis, in short reaction times, of a variety of tertiary alcohols from secondary alcohols through a domino oxidation-addition protocol.